Key result
Fluorescent labeling of skeletal troponin C revealed distinct environmental changes and kinetic processes upon calcium and magnesium binding to high and low affinity sites.
Fluorescence studies reveal distinct kinetic processes and environmental changes in skeletal troponin C upon binding of calcium versus magnesium.
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Should not yet influence clinical practice; leaves open whether these skeletal troponin C kinetics apply to cardiac isoforms.
Iio et al. (1981) studied this question. Fluorescent labeling and Ca2+/Mg2+ binding was evaluated on Fluorescence intensity change and kinetic rate constants. Fluorescent labeling of skeletal troponin C revealed distinct environmental changes and kinetic processes upon calcium and magnesium binding to high and low affinity sites.
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