Key result
Diabetic nephropathy was associated with a markedly higher inactive to active renin ratio in plasma compared to normal subjects (90 vs 9), but similar ratios in the kidneys.
Why the study?
Does the inactive to active renin ratio differ in the kidneys and plasma of patients with diabetic nephropathy compared to normal subjects?
Observational
Does the inactive to active renin ratio differ in the kidneys and plasma of patients with diabetic nephropathy compared to normal subjects?
The increased inactive to active renin ratio in the plasma of patients with diabetic nephropathy does not appear to result from changes in kidney renin storage.
Answers are grounded in this paper and cite their sources.
Plasma inactive renin elevation in diabetic nephropathy may not reflect renal storage; leaves open extrarenal sources or processing for study.
We examined the inactive to active renin ratio in the renin granules of the cadaver kidneys and the plasma in patients with diabetic nephropathy. The inactive renin in the break-through fraction when the plasma or the renin from the renin granules was put into a pepstatin column was determined. The inactive renin in this fraction was activated by trypsin. Concerning plasma, the inactive to active renin ratio was 90 in the patients and 9 in the normal subjects. On the other hand, this ratio was 0.29 in the patients' kidneys and 0.28 in the control kidneys. These results suggest that the increase of the inactive to active renin ratio in plasma of diabetic nephropathy does not result from the change of the renin storage in the kidneys.
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Kawamura et al. (1983) conducted an observational in Diabetic nephropathy. Diabetic nephropathy vs. Normal subjects / control kidneys was evaluated on Inactive to active renin ratio in plasma. Diabetic nephropathy was associated with a markedly higher inactive to active renin ratio in plasma compared to normal subjects (90 vs 9), but similar ratios in the kidneys.
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