What is the clinical evidence from this study?

Study design: Editorial. Population: Hypertension. Intervention: Angiotensin blockade.

What question did this study set out to answer?

To evaluate the causative role of renin and angiotensin II in hypertension and assess the diagnostic utility of competitive angiotensin II receptor antagonists.

March 1, 1977Annals of Internal Medicine

Angiotensin Blockade in Hypertension

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Key result

Angiotensin blockade with competitive antagonists of angiotensin II is discussed to evaluate the role of renin and angiotensin excess in the genesis of hypertension.

Design

Editorial

Authors

DSDavid H. P. StreetenCross-Cutting Cardiology

Discussion

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Implication

This 1977 editorial discusses the emerging role of angiotensin blockade in understanding and managing renin-dependent hypertension.

Key Points

To evaluate the causative role of renin and angiotensin II in hypertension and assess the diagnostic utility of competitive angiotensin II receptor antagonists.
Narrative clinical review analyzing the relationship between plasma renin activity, angiotensin II generation, and blood pressure regulation.
Synthesized findings from clinical applications of competitive angiotensin II antagonists, including saralasin (1-Sar-8-Ala-angiotensin II), in hypertensive patients.
Elevated plasma renin activity does not consistently coincide with high blood pressure, occurring also in normotensive states such as Bartter's syndrome and cirrhosis with ascites.
Competitive blockade using angiotensin II antagonists functionally isolates the hormone's contribution, allowing direct identification of angiotensin-dependent hypertension.

PICO

Population

Hypertension

Intervention / Comparator

Angiotensin blockade

This 1977 editorial discusses the emerging role of angiotensin blockade in understanding and managing renin-dependent hypertension.

Cite This Study

David H. P. Streeten (1977) conducted an editorial in Hypertension. Angiotensin blockade was evaluated. Angiotensin blockade with competitive antagonists of angiotensin II is discussed to evaluate the role of renin and angiotensin excess in the genesis of hypertension.

synapsesocial.com/papers/6a9ba3762072fd8addbb0593 https://doi.org/10.7326/0003-4819-86-3-353

Topics

Hypertension management

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Angiotensin Blockade in Hypertension

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Implication

Key Points

PICO

Cite This Study

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Angiotensin Blockade in Hypertension

Discussion

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Implication

Key Points

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Cite This Study

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