Key result
A soluble preparation of quinidine hydrochloride with urea and antipyrine was proposed for parenteral administration in treating acute cardiac arrhythmias.
Describes the rationale and formulation for a soluble parenteral preparation of quinidine for the emergency treatment of acute cardiac arrhythmias.
Proposed soluble quinidine may aid acute arrhythmia management; leaves open prospective validation of efficacy and safety.
Soluble preparations of quinidine sulfate for parenteral administration have not been readily available. Quinine dihydrochloride has been administered intramuscularly or intravenously. 1 Dilute solutions of quinidine sulfate in dextrose or water 2 and even suspensions of quinidine sulfate tablets in hot water and hydrochloric acid 3 have been administered in emergencies, but there are important objections to these procedures. The necessity for a soluble preparation of quinidine suitable for parenteral administration in treating acute cardiac arrhythmias is obvious, especially when the abnormal rhythm is associated with vomiting, collapse, unconsciousness or other conditions in which absorption from the gastrointestinal tract is uncertain or delayed. A prolonged search of the American market for a soluble preparation has been unsuccessful. The Cinchona Products Institute, however, suggested that such a product might be obtained by adding urea and antipyrine to quinidine hydrochloride according to the following formula: So far as we have been able
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Sturnick et al. (1943) studied Acute cardiac arrhythmias. Soluble preparation of quinidine (quinidine hydrochloride with urea and antipyrine) was evaluated. A soluble preparation of quinidine hydrochloride with urea and antipyrine was proposed for parenteral administration in treating acute cardiac arrhythmias.