Key result
A reduction of the common carotid artery lumen of approximately 45% was necessary before blood flow was reduced in rabbits, with greater stenosis affecting flow more than pressure.
Caution against assuming flow effects from moderate carotid stenosis; extends experimental models but leaves open human translation.
Stenotic lesions of varying magnitudes were induced in the common carotid arteries of rabbits. Resulting alterations in carotid blood flow were correlated with changes in the ocular, external maxillary, long posterior ciliary, and central ear artery pressure pulses. A reduction of the common carotid artery lumen of approximately 45% was necessary before blood flow was reduced. Progressively greater degrees of stenosis had a much greater effect on blood flow than on blood pressure. Changes in the systolic and diastolic portions of the flow pattern were reflected in the ocular and blood vessel pulses by a decrease in amplitude, reduction in slope of the anacrotic and catacrotic limbs, rounding of the crest with a slight delay, or double peaking of the crest and a dicrotic notch that occurred higher than normal on the catacrotic limb or was absent.
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M. Best (1971) studied Carotid Stenosis. Induced stenotic lesions in the common carotid arteries was evaluated on Carotid blood flow and pressure pulses. A reduction of the common carotid artery lumen of approximately 45% was necessary before blood flow was reduced in rabbits, with greater stenosis affecting flow more than pressure.
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