Key result
Cornus mas L. extract improved aorta functions in rats on a high-fat diet, while AuNPsCM enhanced existing aorta wall modifications and altered vessel wall responses.
Why the study?
Vascular reactivity may be influenced by perivascular adipose tissue dysfunction resulting from a prolonged high-fat diet.
RCT (n=28)
randomly allocated
In a rat model of prolonged high-fat diet, simple Cornus mas L. extract improved aortic vascular reactivity, whereas gold nanoparticles phytoreduced with the extract worsened vascular dysfunction.
May support Cornus mas extract for vascular protection in HFD models; leaves open AuNP safety and translational relevance.
Background. Vascular reactivity may be influenced by the dysfunction of the perivascular adipose tissue (PVAT) that occurs after a prolonged high fat diet (HFD). Aim. The aim of this study was to investigate the vascular responses in rats with prolonged HFD after the administration of Cornus mas L. extract as a simple solution or as a reducing agent for gold nanoparticles (AuNPs). Methods. Sprague-Dawley adult female rats (21 animals) were randomly allocated into three groups (n=7) and received for 9 months hyperlipid diet, the last month with treatment administered through oral gavage, 0.5 mL/day of solution as follows: HFD group - 0.9% saline solution, HFD+CM group - Cornus mas L. extract (0.158 mg/mL polyphenols), HFD+AuNPsCM group - gold nanoparticles phytoreduced with Cornus mas L. extract (AuNPsCM, 260 μg Au/kg/day). The Control group of rats (n=7) was fed with standard diet and in the last month received 0.9% saline solution as treatment. At the end of the experiment, the rats’ descending aortas were collected and were used to investigate the aorta wall responses to vasoconstrictor (phenylephrine) and vasodilator (acetylcholine) substances added in tissue bath. Results. AuNPsCM administration, compared to Control and HFD groups, increased the contraction and reduced the relaxation in aorta rings of rats with prolonged high-fat diet. The simple solution of Cornus mas L. extract produced contractile responses similar to those recorded in the Control group, at lower levels than in HFD group, and relaxation responses significantly decreased in comparison with Control group and significant increased when compared to HFD group. Conclusions. Cornus mas L. extract administered as simple solution improved the aorta functions, while AuNPsCM solution enhanced the existed aorta wall modifications occurred after prolonged HFD, altering the vessel wall responses.
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Moldovan et al. (2023) conducted an RCT in hyperlipid diet-induced vascular dysfunction (n=28). Cornus mas L. extract and gold nanoparticles phytoreduced with Cornus mas L. extract (AuNPsCM) vs. 0.9% saline solution was evaluated on aorta wall responses to vasoconstrictor (phenylephrine) and vasodilator (acetylcholine) substances. Cornus mas L. extract improved aorta functions in rats on a high-fat diet, while AuNPsCM enhanced existing aorta wall modifications and altered vessel wall responses.
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