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June 16, 1973BMJOpen Access

Cardiovascular Effects of Acrylic Bone Cement in Rabbits and Cats

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Key result

Forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur in rabbits and cats caused an acute fall in blood pressure within a few seconds of insertion.

Why the study?

Does forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur affect blood pressure in rabbits and cats?

Population

rabbits and cats

Design

Preclinical

Follow-up

acute (within a few seconds)

Authors

DPD. PellingBibra InternationalKBK.R. ButterworthUniversity of London

Discussion

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Member takes

Overview

Suggests non-specific medullary pressurization triggers acute hypotension in animals; leaves open relevance to human cement implantation syndrome.

Structured PICO

Does forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur affect blood pressure in rabbits and cats?

P
Population
rabbits and cats
I
Intervention
forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur
O
Outcome
blood pressure responsesurrogate

Insertion of acrylic bone cement and other substances into the medullary cavity causes an acute fall in blood pressure in animal models, providing insight into cardiovascular complications during human prosthetic hip surgery.

Cite This Study

Pelling et al. (1973) studied this question. Forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur was evaluated on Blood pressure response. Forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur in rabbits and cats caused an acute fall in blood pressure within a few seconds of insertion.

synapsesocial.com/papers/6a9bd0ec0b073dbbe4b20da9https://doi.org/10.1136/bmj.2.5867.638
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac arrest associated with bone cement.1970 · 104 citations
  2. 2Cardiovascular Effects of Implanted Acrylic Bone Cement1971 · 131 citations
  3. 3Total replacement of the hip.1972 · 11 citations
  4. 4Fat Embolism in Patients with Fractured Hips1972 · 63 citations