What does this research mean for the field?

High-risk HPV E6/E7 oncoprotein expression is significantly more prevalent in prostate cancer than in benign prostatic hyperplasia and is independently associated with aggressive tumor traits such as higher Gleason grade and advanced stage. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the presence of high-risk human papillomavirus (HPV) E6/E7 oncoproteins in prostate cancer compared with benign prostatic hyperplasia tissues and assess their relationship with clinicopathological characteristics.

September 5, 2026BMC CancerOpen Access

Immunohistochemical detection of high-risk human papillomavirus E6/E7 oncoproteins is associated with aggressive clinicopathological features in prostate cancer: a Sudanese cohort study

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To evaluate the presence of high-risk human papillomavirus (HPV) E6/E7 oncoproteins in prostate cancer compared with benign prostatic hyperplasia tissues and assess their relationship with clinicopathological characteristics.
Analyzed 100 formalin-fixed, paraffin-embedded prostate tissue specimens (50 histologically confirmed prostate cancer cases and 50 benign prostatic hyperplasia controls) from a Sudanese cohort.
Evaluated high-risk HPV E6/E7 expression using immunohistochemistry with monoclonal antibodies, semi-quantified staining via the H-score system, and evaluated associations using multivariable logistic regression adjusted for prostate-specific antigen.
HPV E6/E7 immunoreactivity was significantly more frequent in prostate cancer than in benign prostatic hyperplasia tissues (48% vs. 18%; OR = 4.21, 95% CI: 1.69–10.43; p = 0.0026).
Positive oncoprotein expression was significantly associated with higher Gleason Grade groups (p = 0.0035) and advanced tumor stages (p = 0.004), remaining an independent predictor after adjusting for serum prostate-specific antigen levels.

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Implication

Retrospective case-control study demonstrates elevated HPV E6/E7 oncoprotein expression in aggressive prostate cancer, suggesting a potential role in tumor progression.

Cite This Study

Elimam et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3a66b95aff0620eac53 https://doi.org/10.1186/s12885-026-16916-0

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Implication

Retrospective case-control study demonstrates elevated HPV E6/E7 oncoprotein expression in aggressive prostate cancer, suggesting a potential role in tumor progression.

Immunohistochemical detection of high-risk human papillomavirus E6/E7 oncoproteins is associated with aggressive clinicopathological features in prostate cancer: a Sudanese cohort study

Key Points

Discussion

Implication

Cite This Study

Immunohistochemical detection of high-risk human papillomavirus E6/E7 oncoproteins is associated with aggressive clinicopathological features in prostate cancer: a Sudanese cohort study

Key Points

Discussion

Implication

Cite This Study

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