What does this research mean for the field?

Norovirus acute gastroenteritis in China imposes a substantial and heterogeneous disease and economic burden, with children under 5 experiencing the highest infection rates and severe manifestations, while the elderly bear the highest individual medical costs. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the epidemiological characteristics, clinical complications, and direct medical costs associated with norovirus-induced acute gastroenteritis across different age groups in China.

September 5, 2026BMC Infectious DiseasesOpen Access

Epidemiological features and direct medical costs of norovirus acute gastroenteritis in China

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Authors

JDJuan Du JZJing Zeng XHXingwen Hu

Discussion

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Overview

Multicenter retrospective study reveals high infection rates and substantial economic burden in gastroenteritis patients, highlighting the need for age-targeted interventions.

Key Points

To evaluate the epidemiological characteristics, clinical complications, and direct medical costs associated with norovirus-induced acute gastroenteritis across different age groups in China.
Conducted a multicenter retrospective study of 23,527 patients with acute gastroenteritis who underwent norovirus testing across medical institutions in four Chinese provinces between 2018 and 2024.
Applied logistic regression models to evaluate infection rates, hospitalization risks, and complications, and integrated findings with national census data to estimate annual direct medical costs.
The overall norovirus positive rate was 18.80% (95% CI 18.30%–19.30%), with significantly higher positivity in inpatients (26.15%, 95% CI 25.28%–27.04%) than outpatients (13.78%, 95% CI 13.21%–14.36%) and highest among children under 5 years (30.49%, 95% CI 29.56%–31.43%).
Concurrent complications developed in 18.97% (95% CI 17.84%–20.16%) of positive cases, led by dehydration (11.28%, 95% CI 10.39%–12.25%) and convulsions (5.52%, 95% CI 4.88%–6.23%).
Median inpatient direct costs were CNY 4,580 (IQR 3,129–6,402) versus CNY 230 (IQR 128–354) for outpatients, contributing to an estimated national annual direct medical burden of CNY 20.23 billion.

Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb575 https://doi.org/10.1186/s12879-026-14337-9

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September 5, 2026BMC Infectious DiseasesOpen Access

Epidemiological features and direct medical costs of norovirus acute gastroenteritis in China

View Full Paper

Ask AI

Bookmark

Authors

JDJuan Du JZJing Zeng XHXingwen Hu

Discussion

Member takes

Overview

Multicenter retrospective study reveals high infection rates and substantial economic burden in gastroenteritis patients, highlighting the need for age-targeted interventions.

Key Points

To evaluate the epidemiological characteristics, clinical complications, and direct medical costs associated with norovirus-induced acute gastroenteritis across different age groups in China.
Conducted a multicenter retrospective study of 23,527 patients with acute gastroenteritis who underwent norovirus testing across medical institutions in four Chinese provinces between 2018 and 2024.
Applied logistic regression models to evaluate infection rates, hospitalization risks, and complications, and integrated findings with national census data to estimate annual direct medical costs.
The overall norovirus positive rate was 18.80% (95% CI 18.30%–19.30%), with significantly higher positivity in inpatients (26.15%, 95% CI 25.28%–27.04%) than outpatients (13.78%, 95% CI 13.21%–14.36%) and highest among children under 5 years (30.49%, 95% CI 29.56%–31.43%).
Concurrent complications developed in 18.97% (95% CI 17.84%–20.16%) of positive cases, led by dehydration (11.28%, 95% CI 10.39%–12.25%) and convulsions (5.52%, 95% CI 4.88%–6.23%).
Median inpatient direct costs were CNY 4,580 (IQR 3,129–6,402) versus CNY 230 (IQR 128–354) for outpatients, contributing to an estimated national annual direct medical burden of CNY 20.23 billion.

Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb575 https://doi.org/10.1186/s12879-026-14337-9

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