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September 5, 2026Journal of Pediatric Intensive Care

Enteral Nutrition Practices during Non-invasive Ventilation in Critically Ill Children: Secondary Analysis of the NIV Dex EN Study

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Authors

CPCharlene PringlePCPeter ChangJCJoie Cavazos

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Overview

Multicenter retrospective study reveals lower failure rates among critically ill children receiving enteral nutrition during non-invasive ventilation, highlighting the need for feeding protocols.

Key Points

  • To describe current enteral nutrition practices, timing, and energy and protein delivery across various non-invasive ventilation modes and interfaces in critically ill pediatric patients.
  • Conducted a secondary analysis of a multicenter retrospective study of N=1763 pediatric patients acutely supported with non-invasive ventilation across 14 intensive care units in the United States over one year.
  • Evaluated the prevalence, routes, timing, and nutrient goal achievements of enteral nutrition, alongside failure rates across non-invasive ventilation modes and interfaces.
  • Enteral nutrition was delivered to 60.4% of patients (n=1065), with fed children being younger than unfed children (median 12 vs 24 months, p<0.001).
  • Patients achieved a median energy delivery of 105% (IQR 79–121%) of target and protein delivery of 79% (IQR 61–86%) of benchmark, predominantly via the gastric route (86.5%).
  • Non-invasive ventilation failure occurred significantly less often in enterally fed patients compared to unfed patients (2.2% [n=24] vs 10.8% [n=76], p<0.0001).

Cite This Study

Pringle et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4346b95aff0620eba51https://doi.org/10.53391/2146-4618.1082
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  4. 4Intermittent enteral nutrition may increase gastrointestinal complications and mortality in critically ill patients2025
  5. 5Early Enteral Nutrition and Clinical Outcomes in Critically Ill Pediatric Populations: A Systematic Review and Meta-Analysis2025