Why the study?
Does prior CABG affect mortality and major complications in patients undergoing TAVIR?
Meta-Analysis
Does prior CABG affect mortality and major complications in patients undergoing TAVIR?
Relative Risk: 0.555 (95% CI 0.35–0.85)
p-value: p=0.006
Patients with prior CABG can safely undergo TAVIR with similar mortality and a lower risk of life-threatening bleeding compared to those without prior CABG.
Background In recent years, many people are opting for minimally invasive surgery in China. Patients undergoing transcatheter aortic valve implantation or replacement (TAVIR) with previous coronary artery bypass grafting (CABG) have higher risks of death and major complications. Materials/methods PubMed and Embase were searched for all comparison studies between TAVIR with and without prior CABG and mortality as a primary outcome, irrespective of surgical risk, to investigate whether patients with prior CABG can undergo TAVIR. Randomized controlled trials and propensity-score-matched cohort studies were eligible for inclusion. The outcomes of interest included 30-day, 6-month, and 1-year mortality and 30-day complications. If significant heterogeneity was found in the random-effects meta-analyses, a sensitivity analysis that individually removed each study was conducted. Results Five studies reported results on patients undergoing TAVIR with or without prior CABG. Compared with the non-CABG cohort, the CABG cohort showed no significant difference in the 30-day, 6-month, and 1-year mortality and the 30-day risk of major complications, except life-threatening bleeding. However, for the 30-day risk of life-threatening bleeding, the morbidity of CABG cohort was significantly lower than that of the non-CABG cohort (risk ratio 0.555; 95% confidence interval 0.35–0.85; P = 0.006; I 2 = 0%). Conclusions Patients with prior CABG can undergo TAVIR. Patients undergoing TAVIR without prior CABG need more attention because of a higher risk of life-threatening bleeding.
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Zheng et al. (2018) conducted a meta-analysis in Patients undergoing transcatheter aortic valve implantation or replacement (TAVIR). Prior coronary artery bypass grafting (CABG) vs. No prior CABG was evaluated on 30-day risk of life-threatening bleeding (RR 0.555, 95% CI 0.35-0.85, p=0.006).
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