Comprehensive Pan-cancer Analysis Identified ZCCHC3 as an Immunological and Prognostic Biomarker

Purpose: ZCCHC3 may be closely associated with the development of tumors. However, the detailed function and role of ZCCHC3 in pan-cancer are largely unknown and require further in-depth investigation. Consequently, this study aims to investigate the biological functions of ZCCHC3, and its potential to predict prognosis and immunotherapy response in pancancer. Methods: We applied multiple public databases such as TCGA, TIMER, GTEx, CCLE, and HPA to explore ZCCHC3 expression in tumors. Univariate Cox regression analysis were used to detect the effects of ZCCHC3 on OS, DSS, DFI, and PFI in these patients. Subsequently, the correlation coefficient between ZCCHC3 levels and immune infiltration in different cancer types was used using TIMER2.0. Finally, the relationship between ZCCHC3 and tumor immune regulatory genes, immune checkpoint, TMB, and MSI were investigated. Results: ZCCHC3 expression was elevated in most tumor tissues compared to normal tissues, and was positively or negatively correlated with the prognosis of different tumors, positively correlated with immune cell infiltration and immune checkpoint gene expression in various tumors. Conclusion: Comprehensive pan-cancer analysis identified ZCCHC3 as an immunological and prognostic biomarker.