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High-Grade Gliomas (HGGs) are the most frequently diagnosed Central Nervous System (CNS) tumors in children. Maximal safe surgical resection is the cornerstone of management of pediatric HGGs. Radiation therapy is the standard of care after surgical resection and significantly improves survival of children older than 3 years-old with HGGs, but the recurrence rate of pediatric HGGs remains very high. Currently, there are no effective treatments for pediatric patients with recurrent HGGs, but inhibition of Vascular Endothelial Growth Factor (VEGF) pathway has shown promising clinical benefit in several clinical studies as it can reduce brain edema, lead to symptomatic relief. Temozolomide (TMZ) is a standard chemotherapeutic modality in treating adult patients with HGGs.
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Li Zhang (2022) studied this question.
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