Key result
Coexpression of the alpha 2/delta-subunit increased the maximal amount of charge moved about twofold and speeded activation and deactivation kinetics in transfected HEK 293 cells.
Coexpression of the alpha 2/delta-subunit enhances the expression of functional cardiac L-type Ca2+ channels and provides evidence regarding nonlinear charge movement during channel state transitions.
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Remains limited to cell models; leaves open whether alpha 2/delta modulation affects native cardiac Ca channel function.
Bangalore et al. (1996) studied this question. Coexpression of the alpha 2/delta-subunit vs. Absence of the alpha 2/delta-subunit was evaluated on Ionic and gating currents (maximal conductance and charge movement). Coexpression of the alpha 2/delta-subunit increased the maximal amount of charge moved about twofold and speeded activation and deactivation kinetics in transfected HEK 293 cells.
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