Key result
Urinary levels of TNF-α and 8-OHdG were independently associated with elevated urinary Angiopoietin-2 levels in type 2 diabetic patients with albuminuria (P<0.001 and P=0.004, respectively).
Observational (n=143)
p-value: p=<0.001
In patients with type 2 diabetes, elevated urinary Angiopoietin-2 levels are associated with increased levels of inflammatory cytokines and reactive oxygen species, suggesting a link between inflammation, oxidative stress, and albuminuria.
Ang-2 links to inflammation and oxidative stress in albuminuric T2DM are hypothesis-generating; prospective studies needed before clinical relevance.
BACKGROUND/AIMS: We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18) and reactive oxygen species (8-OHdG and SOD) in type 2 diabetes patients with albuminuria. METHODS: This retrospective study evaluated 113 patients with type 2 diabetes and normoalbuminuria, microalbuminuria, or macroalbuminuria and 30 healthy controls. Serum and urine TNF-α, IL-18 and 8-OHdG levels were measured by ELISA. Superoxide dismutase (SOD) activity was determined by spectrophotometry. RESULTS: Serum and urine TNF-α, IL-18 and 8-OHdG levels increased significantly with the degree of albuminuria, and were positively correlated with increased Ang-2. In contrast, SOD activity decreased with the degree of albuminuria and was negatively correlated with Ang-2. Multivariable linear regression analysis revealed that serum Ang-2 level was independently associated with serum levels of TNF-α (P<0.001), 8-OHdG (P=0.001), and IL-18 (P=0.003). Urinary Ang-2 level was independently associated with urinary TNF-α (P<0.001) and 8-OHdG (P=0.004) levels. CONCLUSION: TNF-α and 8-OHdG are associated with elevated urinary Angiopoietin-2 levels in type 2 diabetic patients with albuminuria.
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He et al. (2015) conducted an observational in Type 2 diabetes with albuminuria (n=143). TNF-α, IL-18, 8-OHdG, and SOD levels was evaluated on Association of urinary Ang-2 level with urinary TNF-α and 8-OHdG levels (p=<0.001). Urinary levels of TNF-α and 8-OHdG were independently associated with elevated urinary Angiopoietin-2 levels in type 2 diabetic patients with albuminuria (P<0.001 and P=0.004, respectively).
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