What is the clinical evidence from this study?

Study design: RCT. Population: healthy (n=32). Intervention: Prednisolone vs. Placebo. Primary outcome: Fasting Angptl4 levels (p=0.073).

September 12, 2012Socio-Environmental Systems ModelingOpen Access

Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans

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Key result

Prednisolone treatment tended to lower fasting Angptl4 levels (P=0.073) and attenuated the insulin-mediated reduction of Angptl4 levels (P=0.03) in healthy males.

Why the study?

Does prednisolone affect Angptl4 levels and lipid metabolism in healthy males?

Study Design

Type

RCT (n=32)

Blinding

double-blind

Randomization

randomized

Structured PICO

Does prednisolone affect Angptl4 levels and lipid metabolism in healthy males?

Population

32 healthy males (mean age 22 years) treated with prednisolone or placebo for 2 weeks.

Intervention

Prednisolone 30 mg once daily (n = 12) or prednisolone 7.5 mg once daily (n = 12) for 2 weeks.

Comparator

Placebo (n = 8) for 2 weeks.

Outcome

Angptl4 levels and lipid metabolism before and at 2 weeks of treatment, in the fasted state and during a 2-step hyperinsulinemic clamp.surrogate

Main Result

p-value: p=0.073

Insulin lowers plasma Angptl4 levels in humans, an effect that is counteracted by glucocorticoids, highlighting a complex hormonal regulation of lipid metabolism.

Discussion

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Implication

Glucocorticoids may blunt insulin effects on lipid regulators; extends hormonal interplay insights to clinical glucocorticoid use.

Cite This Study

Raalte et al. (2012) conducted an RCT in healthy (n=32). Prednisolone vs. Placebo was evaluated on Fasting Angptl4 levels (p=0.073). Prednisolone treatment tended to lower fasting Angptl4 levels (P=0.073) and attenuated the insulin-mediated reduction of Angptl4 levels (P=0.03) in healthy males.

synapsesocial.com/papers/6a9be9420f482a739018269b https://doi.org/10.1055/s-0032-1321864

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Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider