Key result
Insulin suppresses glucocorticoid-induced Angptl4 transcription via PI3K/Akt signaling by abolishing the recruitment of GR and FoxO1 to the Angptl4 response elements.
Insulin represses glucocorticoid-stimulated Angptl4 transcription by inhibiting FoxO1, demonstrating that both GR and FoxO1 are required for its transcriptional activation.
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Animal data preclude clinical application; leaves open human relevance of insulin-glucocorticoid Angptl4 crosstalk.
Kuo et al. (2014) studied this question. Insulin vs. Glucocorticoid alone / Fasting was evaluated on Angptl4 transcription and gene expression. Insulin suppresses glucocorticoid-induced Angptl4 transcription via PI3K/Akt signaling by abolishing the recruitment of GR and FoxO1 to the Angptl4 response elements.
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