Key result
In 10 patients with bacterial endocarditis, the development or worsening of aortic insufficiency was associated with autopsy-confirmed perforation or rupture of the aortic valve cusps.
Case Report (n=10)
The development of dynamic or worsening aortic insufficiency in bacterial endocarditis is commonly associated with aortic valve cusp perforation or rupture and is an ominous prognostic sign.
Worsening aortic insufficiency may signal cusp perforation in endocarditis; hypothesis-generating for imaging surveillance pending prospective data.
This report describes 10 patients with bacterial endocarditis who during observation developed signs of dynamic aortic insufficiency or experienced marked worsening of the manifestations of pre-existing aortic insufficiency. The autopsy findings in these patients provide evidence that the clinical signs were associated with perforation or rupture of the aortic valve cusps. It is suggested that this sequence of events in the course of bacterial endocarditis is common and that its occurrence must be regarded as an ominous prognostic sign.
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Tompsett et al. (1961) conducted a case report in Bacterial endocarditis (n=10). Bacterial endocarditis was evaluated on Perforation or rupture of the aortic valve cusps at autopsy. In 10 patients with bacterial endocarditis, the development or worsening of aortic insufficiency was associated with autopsy-confirmed perforation or rupture of the aortic valve cusps.
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