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June 3, 2014Australian Dental JournalOpen Access

Protocol in managing oral surgical patients taking dabigatran

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Key result

This review and case series of five patients provides practical clinical advice on managing oral surgical patients taking dabigatran, particularly for extractions.

Why the study?

How should oral surgical patients taking dabigatran be managed to prevent or treat bleeding complications?

Population

5 patients on dabigatran requiring dental treatment, particularly extractions

Design

Case_series

Authors

OBOmar BreikACA. ChengPSPJ Sambrook

Discussion

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Overview

May guide periprocedural dabigatran management in dental extractions; hypothesis-generating and requires prospective validation before practice change.

Key Points

  • To examine the pharmacological profile and bleeding risks of dabigatran and establish clinical guidance for dentists managing patients who need dental extractions.
  • Reviewed the pharmacological properties, safety profiles, and reversal methods of dabigatran relative to conventional anticoagulants.
  • Assessed management protocols and hemostatic outcomes across a case series of five patients taking dabigatran who underwent dental treatment.
  • Dabigatran demonstrated predictable pharmacokinetics and dose responses without requiring routine laboratory monitoring, minimizing complications typical of warfarin and heparin.
  • Identified practical management steps for dental extractions, focusing on timing procedures relative to dosing, using local hemostatic agents, and knowing specific protocols for bleeding reversal.

Structured PICO

How should oral surgical patients taking dabigatran be managed to prevent or treat bleeding complications?

P
Population
5 cases of patients taking dabigatran who required dental treatment, particularly extractions.
E
Exposure
Dental treatment/extractions and bleeding management protocols
O
Outcome
Bleeding complications and their managementsafety

Provides practical clinical advice for dentists on managing bleeding risks in patients taking dabigatran who require oral surgery.

Cite This Study

Breik et al. (2014) conducted a review in Patients taking dabigatran requiring dental treatment (n=5). Dabigatran was evaluated. This review and case series of five patients provides practical clinical advice on managing oral surgical patients taking dabigatran, particularly for extractions.

synapsesocial.com/papers/6a9bf25ce8a813fc4668ee9ahttps://doi.org/10.1111/adj.12199
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombin inhibitors: surgical considerations and pharmacology2013 · 10 citations
  2. 2Dabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity2010 · 1,381 citations
  3. 3Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip Replacement2005 · 296 citations
  4. 4Current concepts of the management of dental extractions for patients taking warfarin2003 · 96 citations
  5. 5In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate2007 · 251 citations