Key result
128-slice MDCT demonstrated moderate to very good agreement with echocardiography for classic Tetralogy of Fallot findings (kappa 0.4-0.8) and was superior in evaluating surgically relevant extra-cardiac anomalies.
Why the study?
No single diagnostic modality suffices for complete preoperative evaluation of tetralogy of Fallot, requiring different imaging tools alone or in combination.
Does 128 MDCT provide better diagnostic evaluation compared to echocardiography in tetralogy of Fallot patients prior to surgical repair?
Observational (n=77)
No
Does 128 MDCT provide better diagnostic evaluation compared to echocardiography in tetralogy of Fallot patients prior to surgical repair?
Effect estimate: k = 0.4 - 0.8
MDCT is a crucial complementary imaging tool to echocardiography for the extra-cardiac evaluation and surgical planning of patients with tetralogy of Fallot.
MDCT may complement echo for extra-cardiac anomalies in TOF; leaves open prospective validation before routine use.
Background Tetralogy of Fallot is the most common congenital cyanotic heart disease. Advances in surgical repair recently facilitate survival of the affected patients into adulthood with good quality of life. Despite imaging plays crucial role in diagnosis of TOF patients, no single diagnostic modality suffices for complete evaluation of TOF. Thus, different diagnostic tools should be used alone or in combination according to patient’s clinical question. This study aims to find out the agreement between the echocardiography and MDCT in evaluation of TOF patients prior to surgical repair. Results Three-step approach used in scanning TOF patients. Firstly, classic TOF findings, MDCT was comparable to echocardiography in overriding aorta (k = 0.6), VSD (k = 0.8), RVH (k = 0.4), and sub valvular pulmonary stenosis (k = 0.6). Echocardiography is superior to MDCT in evaluation of valvular stenosis (k = 0.4). MDCT was superior to echocardiography in supravalvular pulmonary stenosis. Secondary, surgical relevant findings, McGoon ratio calculated in 94.2%, small and major APCs in 45.5% and 28.5% respectively, PDA in 35% and anomalous coronary artery in 5.1%. Thirdly, other TOF-associated anomalies, common: ASD (34.3%) and RAA (28.3%), and persistent LSVC (10.3%). Uncommon: situs ambiguous (2.5 %), PAPVR (1.2%), and IVC anomalies (3.8%). MDCT was superior to echocardiography in surgical relevant findings and other TOF-associated anomalies. Conclusion MDCT is a crucial imaging tool for extra cardiac evaluation of TOF patients prior to surgical repair.
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Moustafa et al. (2021) conducted an observational in Tetralogy of Fallot (n=77). 128-slice MDCT vs. Echocardiography was evaluated on Agreement between MDCT and echocardiography for classic TOF findings (overriding aorta, VSD, RVH, subvalvular pulmonary stenosis) (k = 0.4 - 0.8). 128-slice MDCT demonstrated moderate to very good agreement with echocardiography for classic Tetralogy of Fallot findings (kappa 0.4-0.8) and was superior in evaluating surgically relevant extra-cardiac anomalies.
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