Study of Pattern of Antihypertensive Use in Subjects with Chronic Kidney Disease in A Tertiary Care Hospital

Chronic Kidney Disease (CKD) is an emerging health problem and is one of the major causes of mortality.Hypertension is closely linked with CKD and both these conditions cause severe cardiovascular events.Hence, blood pressure control is imperative in all stages of CKD and this plays a major role in preventing its CKD progression to end stage kidney disease and death.Objectives: To determine the pattern of antihypertensive prescribing among hypertensive CKD patients, with or without other comorbid conditions and to assess the proportion of hypertension in CKD patients.Methodology: 100 consecutive CKD subjects of either gender, attending the outpatient nephrology were included into the study.Using predesigned case record form data was collected about -the antihypertensives used, single and fixed dose combinations, concomitant medications and about number and type of comorbidities.Results: CKD was seen more prevalent in males (72%) compared to females (28%), and majority of the study subjects were in the age group 41-60 years.93% of the study subjects were hypertensives and more than 50% of subjects were not following both physical exercise and dietary measures.In our study most prescribed hypertensive medication as monotherapy was calcium channel blockers (Amlodipine/Cilnidipine/Nicardipine) and fixed dose combination was ARBs + Thiazides and CCBs + Thiazides. Conclusion:The study concluded that though treatment regimen used in our study was not in accordance to the 2021 KDIGO guidelines, (According to 2021 KDIGO guidelines, ACEI/ARB are the first line drugs to treat HTN in CKD patients without dialysis), prescribed antihypertensives were effectively controlled systolic and diastolic blood pressure.