Key result
Graves' disease is linked to a ~71% incidence of MR and higher TR versus controls.
Why the study?
Does Graves' disease increase the incidence of mitral and tricuspid regurgitation compared to healthy controls?
Case-Control (n=100)
Yes
Does Graves' disease increase the incidence of mitral and tricuspid regurgitation compared to healthy controls?
Absolute Event Rate: 71% vs 3%
p-value: p=<0.01
Graves' disease is associated with a significantly higher incidence of mitral and tricuspid regurgitation, with severe tricuspid regurgitation being a potential risk factor for congestive heart failure in these patients.
Graves' disease was associated with higher regurgitation rates; leaves open whether screening or thyroid treatment modifies valvular outcomes.
With two-dimensional (2D) color Doppler echocardiography, the cardiac and valvular function of 24 consecutive patients with a history of Graves' disease (17 were hyperthyroid and 7 were euthyroid at the time of the examination) were evaluated. The incidences of mitral regurgitation (MR), tricuspid regurgitation (TR) and MR plus TR were significantly higher in the patients with Graves' disease than in the age-matched control group of patients without this disease. In the patients who had signs of congestive heart failure (CHF) while they were hyperthyroid, a significantly higher incidence of severe TR was observed. This is the first report of a 2D color Doppler echocardiography study on the incidences of TR and/or MR in patients with Graves' disease. Our data indicate that in Graves' disease valvular dysfunction can be caused by systemic disorders and that severe TR is a possible risk factor for CHF.
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Kage et al. (1993) conducted a case-control in Graves' disease (n=100). Graves' disease vs. Individuals without known cardiovascular or pulmonary diseases was evaluated on Incidence of mitral regurgitation (p=<0.01). Patients with Graves' disease had a significantly higher incidence of mitral regurgitation (71% vs 3%, p<0.01) and tricuspid regurgitation (63% vs 16%, p<0.01) compared to controls.
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