Key result
Medical control of the thyrotoxic state in a 32-year-old woman with Graves' disease reversed severe mitral regurgitation to trace levels and normalized left ventricular function.
Why the study?
Mitral valve prolapse is common in Graves' disease, but severe mitral regurgitation is a relatively uncommon manifestation.
Does medical control of the thyrotoxic state improve severe mitral regurgitation in a patient with Graves' disease?
Case Report (n=1)
Does medical control of the thyrotoxic state improve severe mitral regurgitation in a patient with Graves' disease?
Severe mitral regurgitation and biventricular failure in Graves' disease can be completely reversible with medical management of the thyrotoxic state, potentially avoiding unnecessary valve replacement.
Severe MR may reverse with thyrotoxicosis control in Graves' disease; leaves open generalizability beyond single cases.
Mitral valve prolapse is a common finding in Graves' disease. However, severe mitral regurgitation (MR) is a relatively uncommon manifestation of Graves' disease. We report a case of a 32-year-old woman with toxic Graves' disease and MR. The echocardiogram was suggestive of severe MR with biventricular failure, severe enough to be considered for mitral valve replacement. With medical control of the thyrotoxic state, a repeat echocardiogram revealed only trace MR, with normal left ventricular function. The timely management of the thyrotoxic state in this patient with Graves' disease and moderate to severe MR possibly related to myxomatous degeneration, averted the need for mitral valve replacement.
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Fekri et al. (2021) conducted a case report in Graves' disease and severe mitral regurgitation (n=1). Medical control of thyrotoxic state was evaluated on Mitral regurgitation severity and left ventricular function. Medical control of the thyrotoxic state in a 32-year-old woman with Graves' disease reversed severe mitral regurgitation to trace levels and normalized left ventricular function.
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