Key result
Hyperthyroidism due to Graves' disease was associated with a significantly higher prevalence of mitral valve prolapse compared to healthy controls (16.3% vs 5.4%).
Why the study?
Is mitral valve prolapse more prevalent in patients with hyperthyroidism compared to healthy subjects?
Cross-Sectional (n=301)
Is mitral valve prolapse more prevalent in patients with hyperthyroidism compared to healthy subjects?
Absolute Event Rate: 9.5% vs 5.4%
p-value: p=not significant
Mitral valve prolapse is significantly more prevalent in patients with hyperthyroidism due to Graves' disease compared to healthy controls, but not in those with toxic nodular goitre.
May warrant MVP screening in Graves' hyperthyroidism; hypothesis-generating for causality and needs prospective confirmation.
The prevalence of mitral valve prolapse was investigated in 126 patients with hyperthyroidism due to Graves' disease or toxic nodular goitre and that of hyperthyroidism in 64 patients with mitral valve prolapse. One hundred and eleven asymptomatic healthy subjects comprised a control group. The patients with hyperthyroidism were divided into those with Graves' disease and those with toxic nodular goitre. Of the group as whole, 12 (9.5%) patients had mitral valve prolapse compared with six (5.4%) in the control group, but the difference was not statistically significant. The prevalence of mitral valve prolapse in the patients with toxic goitre was also not significantly different from that in the controls. When the prevalence in the group with Graves' disease was compared with that in the control group (16.3% vs 5.4%) the difference was significant. Only one patient with mitral valve prolapse had hyperthyroidism.
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Brauman et al. (1985) conducted a cross-sectional in Hyperthyroidism and Mitral valve prolapse (n=301). Hyperthyroidism vs. Asymptomatic healthy subjects was evaluated on Prevalence of mitral valve prolapse (p=not significant). Hyperthyroidism due to Graves' disease was associated with a significantly higher prevalence of mitral valve prolapse compared to healthy controls (16.3% vs 5.4%).
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