April 1, 1988Cardiovascular Research
Quantitation of coronary venous adenosine in patients: limitations evaluated by radioimmunoassay
Key result
Coronary venous adenosine concentration did not significantly increase during atrial pacing (106.3 to 114.9 nmol/L, NS) or coronary occlusion, precluding its use as an index of myocardial ischaemia.
Why the study?
Does coronary venous adenosine concentration increase during induced myocardial ischaemia in patients?
Population
15 patients total: 3 with normal coronary arteries, 7 with obstructive coronary artery disease, and 5…
Comparison
Atrial pacing or coronary artery occlusion… vs Rest (baseline measurements)
Design
Cohort
Authors
Discussion
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Implication
Findings do not support coronary venous adenosine as ischaemia marker; leaves open whether half-life or sampling limits detection in future studies.
Study Design
Type
Observational (n=15)
Structured PICO
Does coronary venous adenosine concentration increase during induced myocardial ischaemia in patients?
P
Population
15 patients, including those with normal coronary arteries, obstructive CAD, and those undergoing coronary angioplasty, evaluated for coronary venous adenosine release.
E
Exposure
Atrial pacing or coronary artery occlusion during angioplasty
C
Comparator
Rest (baseline measurements)
O
Outcome
Coronary venous adenosine concentrationsurrogate
Main Result
Absolute Event Rate: 114.9% vs 106.3%
p-value: p=NS
The extremely short half-life of coronary venous adenosine precludes its use as a reliable index of myocardial ischaemia in patients.
Limitations
- The extremely short half life of coronary venous adenosine appears to preclude its use as an index of myocardial ischaemia in patients.
- Importance of time and temperature at low adenosine concentrations had been underestimated in preceding studies.
Cite This Study
Hamm et al. (1988) conducted an observational in Coronary artery disease and myocardial ischaemia (n=15). Atrial pacing and coronary artery occlusion vs. Rest was evaluated on Coronary venous adenosine concentration (p=NS). Coronary venous adenosine concentration did not significantly increase during atrial pacing (106.3 to 114.9 nmol/L, NS) or coronary occlusion, precluding its use as an index of myocardial ischaemia.