Key result
Asymptomatic patients with mitral valve prolapse exhibited higher production of malondialdehyde and plasma beta-thromboglobulin levels compared to normal subjects, indicating platelet hyperactivity.
Why the study?
Do asymptomatic patients with mitral valve prolapse have increased platelet activity compared to normal subjects?
Case-Control (n=57)
Do asymptomatic patients with mitral valve prolapse have increased platelet activity compared to normal subjects?
Asymptomatic patients with mitral valve prolapse exhibit signs of platelet hyperactivity, as evidenced by increased MDA production and plasma BTG levels.
May support platelet hyperactivity in asymptomatic mitral valve prolapse; hypothesis-generating for thrombotic risk studies.
Platelet aggregation, malondialdehyde (MDA) production, and recovery after aspirin (ASA) administration and plasma levels of beta-thromboglobulin (BTG) were determined in 40 asymptomatic patients with mitral valve prolapse (MVP) and 17 normal subjects. Platelet aggregation was similar in patients and controls, although two patients presented spontaneous aggregation. Production of MDA and plasma levels of BTG were higher in MVP than in controls; however, recovery after ASA was similar in both groups. The results further indicate that platelet hyperactivity is present in a significant number of asymptomatic patients with MVP.
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Arocha et al. (1985) conducted a case-control in Mitral valve prolapse (n=57). Mitral valve prolapse vs. Normal subjects was evaluated on Platelet aggregation, malondialdehyde production, plasma beta-thromboglobulin levels, and recovery after aspirin administration. Asymptomatic patients with mitral valve prolapse exhibited higher production of malondialdehyde and plasma beta-thromboglobulin levels compared to normal subjects, indicating platelet hyperactivity.
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