Why the study?
Do patients with mitral valve prolapse have increased platelet coagulant activity compared to controls?
Population
29 patients with mitral valve prolapse, 18 control patients, and 38 normal subjects
Design
Case-control
Authors
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May link mitral valve prolapse to thromboembolism via platelet hyperactivity; hypothesis-generating and requires prospective confirmation.
Do patients with mitral valve prolapse have increased platelet coagulant activity compared to controls?
Patients with mitral valve prolapse exhibit increased platelet coagulation hyperactivity, suggesting a role for platelets in the associated risk of thromboembolism.
Walsh et al. (1981) studied this question.
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