In vitro study demonstrates bacterial cell leakage and antibacterial activity of novel quinazoline-benzodiazepine analogues, highlighting their potential as antimicrobial agents.
Novel quinazoline embellished analogues of 1,5‐benzodiazepine (6, 9, 13, 17, 21 and 24) were synthesized using one‐pot domino approach. Structure of the compounds synthesized, were established with the help of IR, 1H NMR, 13C NMR and mass spectral data. Further, antibacterial activity, FE‐SEM imaging and cell leakage study was also performed.
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Misra et al. (2020) studied this question.
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