Key result
Patients on long-term hemodialysis had significantly lower resting plasma dopamine-beta-hydroxylase activity compared to healthy controls (13.6 vs 28.3 IU/l; p<0.01), suggesting autonomic dysfunction.
Why the study?
Does long-term hemodialysis affect plasma dopamine-beta-hydroxylase activity and autonomic nervous function compared to healthy controls?
Population
12 patients on long-term hemodialysis and an 8-member healthy control group (n=20)
Comparison
Physiological stressors vs Healthy control group
Design
Case-control
Authors
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Lower dopamine-beta-hydroxylase activity may indicate autonomic dysfunction in hemodialysis; hypothesis-generating for prognostic studies.
Case-Control (n=20)
Does long-term hemodialysis affect plasma dopamine-beta-hydroxylase activity and autonomic nervous function compared to healthy controls?
Absolute Event Rate: 13.6% vs 28.3%
p-value: p=<0.01
Patients on long-term hemodialysis exhibit blunted plasma dopamine-beta-hydroxylase activity responses to physiological stressors, suggesting autonomic nervous dysfunction.
Tajiri et al. (2008) conducted a case-control in Long-term hemodialysis (n=20). Long-term hemodialysis vs. Healthy controls was evaluated on Plasma dopamine-beta-hydroxylase (DBH) activity at rest (p=<0.01). Patients on long-term hemodialysis had significantly lower resting plasma dopamine-beta-hydroxylase activity compared to healthy controls (13.6 vs 28.3 IU/l; p<0.01), suggesting autonomic dysfunction.
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