Key result
Immunohistochemical positivity for vimentin, CD10, CD31, and VEGFR-1 established the diagnosis of spindle cell angiosarcoma in an 80-year-old man with a difficult-to-diagnose subcutaneous tumor.
This case highlights the use of histopathology and immunohistochemistry in diagnosing spindle cell angiosarcoma, a rare and difficult-to-diagnose tumor.
80歳代，男性。初診1ヵ月前から，左上腕に皮下腫瘤を自覚し，増大してきたため当科受診した。初診時左上腕伸側に鶏卵大の弾性硬の皮下腫瘤あり。病理組織では境界明瞭な結節性病変で，紡錘形細胞の束状増殖と多形性増殖が認められた。免疫組織化学ではvimentin，CD10，CD31，VEGFR－1陽性，von Willebrand factor，CD34，EMA，D2－40，desmin，SMA，S－100蛋白，CD3，CD79a，CD68，MNF116陰性であった。病理組織像と免疫組織化学よりspindle cell angiosarcomaと診断した。
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峯村 et al. (2012) studied this question. Immunohistochemical positivity for vimentin, CD10, CD31, and VEGFR-1 established the diagnosis of spindle cell angiosarcoma in an 80-year-old man with a difficult-to-diagnose subcutaneous tumor.
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