Key result
Afferent splanchnic nerve stimulation caused depressor responses at all frequencies in spontaneously hypertensive rats, contrasting with frequency-dependent responses in normotensive rats.
Why the study?
Does afferent splanchnic nerve stimulation elicit different cardiovascular responses in spontaneously hypertensive rats compared to normotensive rats?
Does afferent splanchnic nerve stimulation elicit different cardiovascular responses in spontaneously hypertensive rats compared to normotensive rats?
Central integrated mechanisms for cardiovascular state changes evoked by visceral afferents may differ between established hypertensive and normotensive rats.
Differential responses suggest altered central integration of visceral afferents in hypertension; hypothesis-generating for neuromodulation targets, pending translational studies.
Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that the central integrated mechanisms for activating a cardiovascular state change as evoked by visceral afferents may differ in the established hypertensive rat from that of the normotensive.
No takes yet. Share an insight, caveat, or question.
Koyama et al. (1985) studied Hypertension. Afferent splanchnic nerve stimulation vs. Normotensive Wistar Kyoto rats was evaluated on Cardiovascular response (depressor and pressor responses). Afferent splanchnic nerve stimulation caused depressor responses at all frequencies in spontaneously hypertensive rats, contrasting with frequency-dependent responses in normotensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: