Population
slow-twitch soleus muscles
Comparison
muscle unloading (for 2, 4, 7, and 10 days) vs control soleus muscles
Design
Preclinical
Follow-up
up to 10 days
Authors
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Supports unloading-induced SERCA1 transcriptional activation in animal muscle; leaves open relevance to human disuse atrophy.
Muscle unloading induces transcriptional activation of the endogenous SERCA1 gene, as evidenced by parallel increases in SERCA1 pre-mRNA and mRNA.
Peters et al. (1999) studied this question.
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