What is the clinical evidence from this study?

Study design: Case Report. Population: Supraventricular tachycardias (n=2). Intervention: Oral amiodarone. Primary outcome: Symptomatic life-threatening ventricular tachyarrhythmias with changing QRS axes (resembling torsades de pointes).

What question did this study set out to answer?

To describe the occurrence of life-threatening ventricular tachyarrhythmias triggered by oral amiodarone administration.

March 1, 1985Human ToxicologyOpen Access

Life-threatening Ventricular Arrhythmias Provoked by Amiodarone Treatment

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Key result

Oral amiodarone treatment for supraventricular tachycardias provoked symptomatic life-threatening ventricular tachyarrhythmias resembling torsades de pointes in two patients.

Why the study?

Can oral amiodarone provoke life-threatening ventricular arrhythmias in patients treated for supraventricular tachycardias?

Population

2 patients with supraventricular tachycardias

Design

Case_report

Follow-up

Several days

Authors

CKCR KumanaSt. Joseph Hospital PTPaul H. TanserDeakin University JEJ. EydtSt. Joseph's Hospital

Discussion

Member takes

Implication

Amiodarone may provoke torsades-like arrhythmias in SVT; case report leaves open incidence and causality.

Key Points

To describe the occurrence of life-threatening ventricular tachyarrhythmias triggered by oral amiodarone administration.
Clinical evaluation of two patients (N=2) receiving oral amiodarone for the treatment of supraventricular tachycardias.
Serial electrocardiographic monitoring and assessment of serum electrolytes and concurrent medications during adverse events.
Both patients developed symptomatic ventricular tachyarrhythmias with fluctuating QRS axes resembling torsades de pointes several days after starting oral amiodarone.
Electrocardiography revealed QT prolongation concurrent with the onset of arrhythmias.
Ventricular arrhythmias completely resolved following the withdrawal of amiodarone in the absence of identifiable electrolyte abnormalities or interacting drugs.

Study Design

Type

Case Report (n=2)

Structured PICO

Can oral amiodarone provoke life-threatening ventricular arrhythmias in patients treated for supraventricular tachycardias?

Population

Two patients treated for supraventricular tachycardias with oral amiodarone.

Exposure

Oral amiodarone

Outcome

Development of symptomatic life-threatening ventricular tachyarrhythmias with changing QRS axes (resembling torsades de pointes)safety

Oral amiodarone can provoke life-threatening ventricular tachyarrhythmias resembling torsades de pointes associated with QT prolongation.

Cite This Study

Kumana et al. (1985) conducted a case report in Supraventricular tachycardias (n=2). Oral amiodarone was evaluated on Symptomatic life-threatening ventricular tachyarrhythmias with changing QRS axes (resembling torsades de pointes). Oral amiodarone treatment for supraventricular tachycardias provoked symptomatic life-threatening ventricular tachyarrhythmias resembling torsades de pointes in two patients.

synapsesocial.com/papers/6a9c3930dfa3a96871850ddc https://doi.org/10.1177/096032718500400207

Topics

Atrial fibrillation Persistent AF management

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Life-threatening Ventricular Arrhythmias Provoked by Amiodarone Treatment

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Life-threatening Ventricular Arrhythmias Provoked by Amiodarone Treatment

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider