Key result
Amiodarone induces life-threatening polymorphic VT and extreme QT prolongation, resolving ~4 days after withdrawal.
Why the study?
Amiodarone, despite its effectiveness as an antiarrhythmic agent, may induce serious polymorphous ventricular tachycardia associated with marked QT prolongation.
Case Report (n=1)
Amiodarone can induce life-threatening polymorphous ventricular tachycardia associated with marked Q-T interval prolongation, which resolves upon drug withdrawal.
Answers are grounded in this paper and cite their sources.
Amiodarone-induced PVT with marked QT prolongation warrants prompt withdrawal; this case leaves open incidence and risk factors.
We report the case of a patient who developed a life-threatening polymorphous ventricular tachycardia ( PVT ) after six weeks of treatment with amiodarone. The Q-T interval was markedly prolonged at 0.86 second. The drug induction of PVT was strongly suggested by the fact that PVT resolved four days after withdrawal of amiodarone when the Q-T interval had shortened to 0.60 second; the arrhythmia has not recurred in the nine months of follow-up since then. Amiodarone, though a very effective antiarrhythmic agent, may induce serious PVT .
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Bhandari et al. (1984) conducted a case report in Polymorphous ventricular tachycardia (n=1). Amiodarone was evaluated on Development of polymorphous ventricular tachycardia and Q-T interval prolongation. Amiodarone treatment induced life-threatening polymorphous ventricular tachycardia and marked Q-T interval prolongation, which resolved four days after drug withdrawal.
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