Key result
Non-obese NAFLD in young women was associated with significantly longer interatrial electromechanical delay compared to healthy controls (16.1 vs. 12.5 ms; p<0.001).
Why the study?
Obese NAFLD increases the risk of atrial fibrillation, but the effect of NAFLD on structural and electrical cardiac functions in non-obese patients without known AF risk factors was unknown.
Does non-obese NAFLD increase inter- and intra-atrial electromechanical delay and cause subclinical structural changes in young women?
Observational (n=74)
Does non-obese NAFLD increase inter- and intra-atrial electromechanical delay and cause subclinical structural changes in young women?
Absolute Event Rate: 16.1% vs 12.5%
p-value: p=<0.001
Non-obese NAFLD in young women is associated with prolonged inter- and intra-atrial electromechanical delay and subclinical structural changes, suggesting a potential early mechanism for increased atrial fibrillation risk.
Prolonged interatrial delay in non-obese NAFLD may mark early atrial remodeling; leaves open AF risk implications pending prospective data.
Background Obese non-alcoholic fatty liver disease (NAFLD) was found to increase the risk of developing atrial fibrillation (AF) regardless of the metabolic syndrome subgroups that may accompany it. In this study, the effect of NAFLD on the structural and electrical functions of the heart was investigated using tissue Doppler echocardiography (TDE) in non-obese NAFLD patients without any known risk factors for AF.Material and methods The study included 43 female patients (31.3±3.8 years), who had stage 2-3 hepatosteatosis detected by liver ultrasonography and diagnosed as non-obese NAFLD (patient group), and 31 healthy women (control group, 32.5±3.6 years). In addition to standard echocardiographic parameters, inter- and intra-atrial electromechanical delay (EMD) were evaluated by TDE.Results Interatrial EMD (PA lateral - PA tricuspid) and intraatrial EMD (PA septum - PA tricuspid) were significantly longer in patient group (16.1±3.4 vs. 12.5±2.3 ms, p<0.001, and 8.4±1.6 vs. 6.6±1.6 ms, p<0.001, respectively). At the subclinical level. atrial size, left ventricular diastolic function, and left ventricular wall thickness measurements were greater in the patient group.Conclusion Inter-atrial and intra-atrial EMD were detected in young women with non-obese NAFLD. In addition, at the subclinical level, structural and functional impairment was detected However, large-volume prospective studies are required to cobfirm these findings regarding the development of AF in non-obese NAFLD patients.
No takes yet. Share an insight, caveat, or question.
Aksu et al. (2021) conducted an observational in Non-obese non-alcoholic fatty liver disease (NAFLD) (n=74). Non-obese NAFLD vs. Healthy women was evaluated on Interatrial electromechanical delay (PA lateral - PA tricuspid) (p=<0.001). Non-obese NAFLD in young women was associated with significantly longer interatrial electromechanical delay compared to healthy controls (16.1 vs. 12.5 ms; p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: