Key result
Co-administration of clopidogrel significantly altered the mean resident time of donepezil in rats (p=0.012), whereas aspirin showed no significant pharmacokinetic interaction.
Clopidogrel may interact with donepezil in rats; leaves open clinical relevance for patients on antiplatelet therapy.
The present study aims to investigate the possibility of interaction of aspirin (Asp) or clopidogrel (CG) on donepezil (DP) hydrochloride in rats by HPLC-fluorescence detection. The separation of DP was achieved in ca. 13 min without interference of Asp and CG on the chromatogram. DP levels in rat plasma with a single administration of DP (5 mg/kg, i.p., group I) and those with a co-administration of Asp (200 mg/kg, p.o., group II or 200 mg/kg, i.p., group III) or CG (5 mg/kg, p.o., group IV) were monitored. The DP concentrations determined in rat plasma ranged from 25.0 to 336.1 ng/mL. Pharmacokinetic parameters for these groups were calculated and compared with one another. No significant difference was observed on the comparison of group I with other groups except for the mean resident time of group IV (p = 0.012). These basic findings may help clinical inference when DP is co-administered with Asp and CG to human.
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Wada et al. (2007) studied this question. Aspirin or clopidogrel co-administration vs. Donepezil alone (5 mg/kg, i.p.) was evaluated on Pharmacokinetic parameters (including mean resident time) (p=0.012). Co-administration of clopidogrel significantly altered the mean resident time of donepezil in rats (p=0.012), whereas aspirin showed no significant pharmacokinetic interaction.
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