Key result
Dipaxin demonstrated an induction period of 48 to 60 hours and a recovery period of 10 to 15 days, with unusually stable prothrombin levels and transient bleeding in 2 of 80 patients.
Why the study?
What are the induction, recovery, and maintenance characteristics of the anticoagulant 2-diphenylacetyl-l,3-indandione in patients?
Observational (n=80)
What are the induction, recovery, and maintenance characteristics of the anticoagulant 2-diphenylacetyl-l,3-indandione in patients?
2-diphenylacetyl-l,3-indandione is an effective anticoagulant that provides stable maintenance prothrombin levels, though it has a prolonged recovery period of 10-15 days that can be reversed with vitamin K1.
Prolonged recovery warrants caution with Dipaxin; Level 5 data leaves open comparative efficacy versus established anticoagulants.
Prothrombin levels as measured by the one-stage whole-plasma and the two-stage technics were followed in 80 patients receiving Dipaxin. The induction period is similar to that for Tromexan, namely, 48 to 60 hours and the recovery period 10 to 15 days which is somewhat longer than in the case of either Tromexan or Dicumarol. This recovery period is hastened to some degree by the administration of water-soluble vitamin K preparations and materially accelerated by vitamin K 1 . The prothrombin level during maintenance therapy is unusually stable. Transient bleeding occurred in two patients. No other toxic effects were observed.
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Pascale et al. (1954) reported an observational. Dipaxin was evaluated on Prothrombin levels (induction and recovery periods). Dipaxin demonstrated an induction period of 48 to 60 hours and a recovery period of 10 to 15 days, with unusually stable prothrombin levels and transient bleeding in 2 of 80 patients.
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