Key result
Vitamin K1 emulsion rapidly counteracts phenylindanedione-induced hypoprothrombinemia, with an optimum emergency dose of 5 mg per kg.
Why the study?
Does vitamin K1 emulsion rapidly counteract phenylindanedione-induced hypoprothrombinemia?
Does vitamin K1 emulsion rapidly counteract phenylindanedione-induced hypoprothrombinemia?
Vitamin K1 emulsion is an effective and rapid antidote for phenylindanedione-induced hypoprothrombinemia, with a recommended emergency dose of 5 mg/kg.
May support emergency reversal with vitamin K1 emulsion; leaves open prospective validation beyond Level 5 evidence.
Abstract 1. Phenylindanedione-induced hypoprothrombinemia is rapidly counteracted by a vitamin K1 emulsion. This hypoprothrombinemia is antagonized at a more rapid rate than that induced by any of the other commonly employed prothrombopenic agents. 2. The optimum dose of the vitamin K1 emulsion in emergency is 5 mg. per Kg. Since a refractoriness to the prothrombopenic action of phenylindanedione ensues, smaller doses should be used in situations where there is to emergency.
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Guttas et al. (1953) studied Phenylindanedione-induced hypoprothrombinemia. Vitamin K1 emulsion was evaluated on Reversal of hypoprothrombinemia. Vitamin K1 emulsion rapidly counteracts phenylindanedione-induced hypoprothrombinemia, with an optimum emergency dose of 5 mg per kg.
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