Why the study?
Does vitamin K1 or menadione improve hypoprothrombinemia induced by anticoagulants?
Does vitamin K1 or menadione improve hypoprothrombinemia induced by anticoagulants?
Oral vitamin K1 is more effective than menadione in reversing hypoprothrombinemia induced by various anticoagulants.
Supports oral vitamin K1 over menadione for reversal; hypothesis-generating and should not change practice.
The effect of synthetic vitamin K and vitamin K1 in hypoprothrombinemia induced by dicoumarol, tromexan and phenylindanedione has been studied.Menadione exerts an equally vigorous effect on dicoumarol, tromexan and P.I.D., and the effect is alike whether the substance is administered by mouth or intramuscularly. The effect is highly varyable from one patient to another.Vitamin K1 administered by mouth also exerts a uniform effect on the three anticoagulants mentioned; its effect is more vigorous than that of menadione.
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And et al. (1953) studied this question.
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