Key result
Low-dose subcutaneous vitamin K1 is linked to faster return to safe INR than withholding acenocoumarol.
Why the study?
Does low-dose subcutaneous vitamin K1 improve the time to reach a safe INR range compared to withholding acenocoumarol in patients with excessive anticoagulation?
Cohort
Yes
Does low-dose subcutaneous vitamin K1 improve the time to reach a safe INR range compared to withholding acenocoumarol in patients with excessive anticoagulation?
p-value: p=0.01
Low-dose subcutaneous vitamin K1 is more effective than simply withholding the drug for rapidly correcting excessive anticoagulation induced by acenocoumarol.
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May hasten INR correction in over-anticoagulated patients; hypothesis-generating and requires RCT confirmation before practice change.
Ortín et al. (1998) conducted a cohort in Excessive anticoagulation episodes induced by acenocoumarol. Low-dose subcutaneous vitamin K1 vs. Short-term withholding of acenocoumarol was evaluated on Time to bring INR to a safe range (p=0.01). Low-dose subcutaneous vitamin K1 brought INR to a safe range faster than short-term withholding of acenocoumarol in patients with excessive anticoagulation (p=0.01).
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