Key result
Boldine attenuates isoproterenol-induced cardiac hypertrophy, increases diastolic volume, and reduces lipid peroxidation in rats.
Why the study?
Sustained adrenergic overload causes maladaptive cardiac remodelling involving oxidative stress, and the antioxidant boldine represents a potential novel cardioprotective therapeutic approach.
Does boldine reduce adverse left ventricular remodeling and oxidative stress in a rat model of isoproterenol-induced adrenergic overload?
Does boldine reduce adverse left ventricular remodeling and oxidative stress in a rat model of isoproterenol-induced adrenergic overload?
p-value: p=<0.05
In a rat model, boldine attenuates cardiac hypertrophy, diastolic volume increases, and oxidative stress caused by isoproterenol-induced adrenergic overload.
Does not support clinical use of boldine; hypothesis-generating for its role in adrenergic cardiac remodeling.
Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel therapeutic approach. This study explored the cardioprotective role of BOL in adverse left ventricular remodelling induced by isoproterenol. The rats were divided into four groups: control; BOL (25 mg/kg daily); isoproterenol (ISO) (5 mg/kg daily), and ISO + BOL. Morphometric, echocardiographic, and oxidative stress parameters were evaluated. BOL attenuated both cardiac hypertrophy and increased diastolic volume caused by adrenergic overstimulation (P < 0.05). BOL treatment reduced lipid peroxidation induced by ISO (ISO vs. ISO + BOL; P < 0.05), and this effect was associated with increased superoxide dismutase (SOD) (ISO vs. ISO + BOL; P < 0.05) and glutathione-S-transferase levels (GST) (ISO vs. ISO + BOL; P < 0.05). This data suggest that BOL may improve cardiac oxidative stress and attenuate some parameters of adverse cardiac remodelling.
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Fernandes et al. (2024) studied Isoproterenol-induced adverse left ventricular remodelling. Boldine vs. Isoproterenol alone and control was evaluated on Cardiac hypertrophy, diastolic volume, and oxidative stress parameters (p=<0.05). Boldine attenuated cardiac hypertrophy, increased diastolic volume, and reduced lipid peroxidation induced by isoproterenol in rats (P < 0.05).
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