Key result
OLF-1, OLF-2, and V-diascorbate increased intracellular free calcium in rat vascular smooth muscle cells (e.g., OLF-1 increased levels from 45 to 99 nmol/L; P<0.05).
Population
Cultured rat vascular smooth muscle (VSM) cells
Comparison
Urinary OLF-1, OLF-2 (approximately 10 mol/L)… vs Ouabain (10 mol/L), angiotensin II (10 mol/L)…
Design
Preclinical
Follow-up
up to 10 minutes
Authors
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Does not alter hypertension management; leaves open a role for these factors in human volume-dependent hypertension.
p-value: p=<.05
Endogenous ouabain-like factors and vanadium-diascorbate increase intracellular calcium in vascular smooth muscle cells, mimicking ouabain and potentially contributing to the pathogenesis of volume-dependent hypertension.
Meyer-Lehnert et al. (2000) studied this question. Ouabain-like factors (OLF-1, OLF-2) and vanadium-diascorbate vs. Ouabain, Angiotensin II, and Arginine-vasopressin was evaluated on Intracellular free calcium ([Ca2+]i) (p=<.05). OLF-1, OLF-2, and V-diascorbate increased intracellular free calcium in rat vascular smooth muscle cells (e.g., OLF-1 increased levels from 45 to 99 nmol/L; P<0.05).
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