Key result
Salivary adiponectin levels were elevated in children with a maternal family history of diabetes compared to those without.
Why the study?
Adiponectin has emerged as a potential indicator of diabetes risk, but its role as a predictive marker in children with or without a family history of diabetes mellitus needed evaluation.
Cross-Sectional (n=125)
No
Children with a family history of diabetes exhibit altered serum and salivary adiponectin levels, which may serve as early indicators of metabolic changes.
Answers are grounded in this paper and cite their sources.
Suggests adiponectin as potential early marker in familial diabetes risk; hypothesis-generating, requires prospective validation before clinical use.
Diabetes mellitus (DM) is a chronic, metabolic condition marked by defects in insulin production, action, or both. Environmental and genetic factors can contribute to the onset of diabetes mellitus. Adiponectin, a hormone affecting pancreatic beta cell proliferation, has emerged as a potential indicator of diabetes risk. This cross-sectional study aimed to evaluate serum and salivary adiponectin levels as predictors of diabetes mellitus in children with/without a family history of diabetes mellitus. The study was conducted at Al-Zahra Hospital in Najaf city and included 125 children aged 5 to 16. Data on demographics, including name, age, and gender, were collected, and body mass index (BMI) was assessed. Serum and salivary adiponectin levels were measured and analyzed in relation to family history and BMI. Children with a family history of DM had high serum adiponectin (ADP) levels. Serum adiponectin levels were significantly higher in children with first-degree relatives having a history of diabetes mellitus, except for cases involving mothers and other relatives with diabetes mellitus history (p<0.05). Furthermore, serum adiponectin levels were higher in obese children. Salivary adiponectin levels were significantly elevated in children with a maternal family history of diabetes (p=0.01), while no significant correlation was found with BMI. A significant negative correlation (r=-0.180, p=0.05) between salivary and serum adiponectin concentrations was observed. Compared to children with a normal, healthy weight, children with obesity had decreased salivary adiponectin levels and increased serum adiponectin levels.
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Merzah et al. (2023) conducted a cross-sectional in Family history of diabetes mellitus (n=125). Maternal family history of diabetes vs. No maternal family history of diabetes was evaluated on Salivary adiponectin levels (ng/ml) (p=0.01). Salivary adiponectin levels were elevated in children with a maternal family history of diabetes compared to those without.
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