Key result
Circulating periostin levels were higher in patients with diffuse systemic sclerosis compared to healthy controls and correlated with the extent of skin fibrosis and left ventricular mass.
Why the study?
The study was conducted to evaluate periostin levels in patients with systemic sclerosis and assess their association with disease features.
Observational (n=128)
No
Answers are grounded in this paper and cite their sources.
Periostin is elevated in systemic sclerosis and correlates with skin fibrosis and left ventricular mass, suggesting it may serve as a biomarker for cardiac involvement in SSc.
OBJECTIVE: To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of systemic sclerosis. METHODS: The levels of periostin were assessed in the serum of 106 SSc patients and 22 healthy controls and by immunofluorescence staining in cardiac tissue from 4 SSc patients and 4 controls. Serum periostin was measured via enzyme-linked immunosorbent assay. The results were analyzed using Mann-Whitney test or Kruskal-Wallis test followed by Dunn's multiple comparisons tests and Spearman's test for correlations. Cardiac tissue from SSc patients and controls was stained for periostin and co-stained for periostin and collagen type I using immunofluorescence. RESULTS: Periostin levels were higher in patients with SSc compared to controls and directly correlated to modified Rodnan skin score and echocardiography parameters of left ventricular measurements. Immunofluorescence staining in SSc cardiac tissue showed patchy periostin expression in all SSc patients, but not in controls. Furthermore, there was extensive periostin expression even in areas without collagen deposition, while all established fibrotic areas showed colocalization of collagen and periostin. There was no association between periostin levels and interstitial lung disease, pulmonary hypertension or other vascular complications. CONCLUSION: Periostin is elevated in SSc cardiac tissue in vivo and circulating levels of periostin are increased in SSc, correlating with the extent of disease duration, degree of skin fibrosis, and left ventricular structural assessments. Periostin may be a potential biomarker that can provide further pathogenic insight into cardiac fibrosis in SSc.
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El-Adili et al. (2022) conducted an observational in Systemic Sclerosis (n=128). Systemic sclerosis vs. Healthy controls was evaluated on Serum periostin levels (p=<0.0001). Circulating periostin levels were higher in patients with diffuse systemic sclerosis compared to healthy controls and correlated with the extent of skin fibrosis and left ventricular mass.
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