Key result
In patients with preoperative tricuspid regurgitation ≥2/4, isolated mitral valve surgery was associated with a higher risk of cardiac mortality or heart failure hospitalization compared to concomitant tricuspid annuloplasty.
Why the study?
Does concomitant tricuspid annuloplasty reduce cardiac mortality or heart failure hospitalization in patients with preoperative tricuspid regurgitation ≥2/4 undergoing mitral valve surgery?
Cohort (n=150)
No
Does concomitant tricuspid annuloplasty reduce cardiac mortality or heart failure hospitalization in patients with preoperative tricuspid regurgitation ≥2/4 undergoing mitral valve surgery?
Concomitant tricuspid annuloplasty during mitral valve surgery in patients with moderate-to-severe tricuspid regurgitation significantly reduces the long-term risk of cardiac mortality and heart failure hospitalization.
Answers are grounded in this paper and cite their sources.
May support concomitant annuloplasty for moderate-to-severe TR during mitral surgery; leaves open need for randomized confirmation.
OBJECTIVE: The clinical benefit of tricuspid annuloplasty (TA) in patients undergoing mitral valve surgery (MVS) is still debated. We evaluated the immediate surgical success, postoperative outcome and the medium-term effect of TA in MVS. METHODS: Patients were included between September 2003 and December 2009 and followed until September 2013 to achieve a median follow-up time of 5 years (IQR 3.7-6.9). The end point of mortality due to cardiac causes and combined end point of cardiac mortality or hospitalisation for heart failure were evaluated. Propensity score adjusted Cox regression was used to evaluate the clinical benefit of TA at the time of MVS. RESULTS: Of 150 patients (84 female; 67±12 years), 82 presented with tricuspid regurgitation (TR) <2/4 and underwent isolated MVS. Of 68 patients presenting with TR≥2/4, 31 underwent isolated MVS whereas 37 underwent additional TA. In patients with preoperative TR≥2/4, TR was significantly reduced until 5 years postoperatively (mean reduction 0.81±1.31; p=0.04) when additional TA was done. The combined end point occurred in 29% vs 6% at 1 year and in 57% vs 39% at 5 years follow-up for patients with isolated MVS and patients undergoing concomitant TA, respectively. Patients with preoperative TR≥2/4 had worse unadjusted survival than those with TR<2/4 (logrank p=0.009). In the patients with TR≥2/4, propensity score-adjusted risk for the combined end point was higher in those with isolated MVS versus MVS with additional TA (Cox HR 2.855 (1.082-7.532), p=0.035). CONCLUSIONS: Additional TA is an effective surgical measure to reduce functional TR severity. This approach results in a decreased risk of cardiac mortality and hospitalisation in patients with preoperative TR≥2/4.
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Meester et al. (2015) conducted a cohort in Mitral valve disease with or without functional tricuspid regurgitation (n=150). Concomitant tricuspid annuloplasty vs. Isolated mitral valve surgery was evaluated on Combined endpoint of cardiac mortality or hospitalization for heart failure (HR 2.855, 95% CI 1.082-7.532, p=0.035). In patients with preoperative tricuspid regurgitation ≥2/4, isolated mitral valve surgery was associated with a higher risk of cardiac mortality or heart failure hospitalization compared to concomitant tricuspid annuloplasty.
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