Key result
Ischemic preconditioning with 4-5 minutes of ischemia protected isolated human myocardium against ischemia (CK 3.06 vs 5.56 U/g; P<0.05), with a potent early window (≤2 h) and a weaker delayed window (24 h).
Why the study?
Does ischemic preconditioning improve cell viability and reduce myocardial injury in isolated human myocardium subjected to ischemia?
Population
Isolated human right atrial appendages obtained during coronary bypass surgery (n=6/group)
Comparison
Ischemic preconditioning protocols vs Ischemia alone
Design
Preclinical
Follow-up
120 minutes of reperfusion
Authors
Loading...
Hypothesis-generating for early-window preconditioning in human myocardium; clinical translation requires prospective in vivo trials.
Does ischemic preconditioning improve cell viability and reduce myocardial injury in isolated human myocardium subjected to ischemia?
Absolute Event Rate: 3.06% vs 5.56%
p-value: p=< 0.05
In isolated human myocardium, ischemic preconditioning provides maximal protection with a 4-5 minute ischemic stimulus, demonstrating a potent early window of protection (<2 hours) and a less potent delayed window (24 hours).
Sudip Ghosh (2000) studied Ischemic preconditioning. Ischemic preconditioning vs. Ischemia alone was evaluated on Leakage of creatinine kinase (CK, U/g wet wt) and reduction of MTT (OD/mg wet wt) (p=< 0.05). Ischemic preconditioning with 4-5 minutes of ischemia protected isolated human myocardium against ischemia (CK 3.06 vs 5.56 U/g; P<0.05), with a potent early window (≤2 h) and a weaker delayed window (24 h).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: