Key result
Review details two lineage-tracing transgenic mouse models used to track cardiomyocyte proliferation and fate.
Why the study?
Adult mammalian cardiomyocytes have low turnover and undergo irreversible loss after myocardial injury, necessitating in vivo lineage tracing methods to characterize their proliferative capacity.
Comparison
Mosaic analysis with double markers vs rainbow reporter system transgenic mouse models
Design
Review
Authors
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Enhances preclinical lineage tracing of cardiomyocyte dynamics; leaves open translation to human heart regeneration.
This review highlights the utility of mosaic analysis with double markers and rainbow reporter systems in tracking cardiomyocyte proliferation and heart regeneration.
Kolluri et al. (2022) conducted a review in Myocardial injury and heart regeneration. Lineage tracing models (mosaic analysis with double markers and rainbow reporter system) was evaluated. This paper reviews two well-studied lineage-tracing transgenic mouse models—mosaic analysis with double markers and the rainbow reporter system—used to track cardiomyocyte proliferation and fate.