Key result
Systemic inflammatory activation plays a role in the etiology of potentially reversible heart failure, which can be modified by specific strategies.
This review highlights that heart failure can be reversible when driven by systemic inflammation and discusses strategies to modify the inflammatory response.
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Inflammation-targeted approaches may aid reversible HF phenotypes; leaves open need for prospective trials before practice change.
Heart failure is increasingly common in western populations and is an inevitable consequence of the improved survival after myocardial infarction, and of an ageing population. Heart failure is usually relentlessly progressive as the maladaptive processes triggered by the physiological changes of the condition lead to further deterioration. However, in certain circumstances, heart failure is transient or potentially reversible when it occurs as part of intense systemic inflammatory activation. This review considers the role of inflammation in the aetiology of heart failure, and illustrates the strategies which have been used to modify the inflammatory response with anonymised clinical case reports.
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Robinson et al. (2010) conducted a review in Heart failure. Inflammation was evaluated. Systemic inflammatory activation plays a role in the etiology of potentially reversible heart failure, which can be modified by specific strategies.
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