Key result
Symbolic analysis demonstrated that sympathetic modulation is reduced in a rat model of chronic heart failure and restored to basal values following treatment with spironolactone.
Why the study?
Does spironolactone restore autonomic cardiovascular modulation in a rat model of chronic heart failure?
Does spironolactone restore autonomic cardiovascular modulation in a rat model of chronic heart failure?
A symbolic approach to analyzing pulse interval and systolic arterial pressure successfully detects changes in autonomic modulation in heart failure rats treated with spironolactone, outperforming traditional spectral indexes.
Answers are grounded in this paper and cite their sources.
Animal data support autonomic effects of spironolactone in experimental HF; leaves open clinical translation and human validation.
We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one.
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Tobaldini et al. (2009) studied Chronic heart failure (animal model). Spironolactone vs. Controls and untreated CHF animals was evaluated on Sympathetic modulation assessed by symbolic analysis. Symbolic analysis demonstrated that sympathetic modulation is reduced in a rat model of chronic heart failure and restored to basal values following treatment with spironolactone.
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