Key result
The NRF 5'UTR acts as a highly efficient internal ribosome entry site, directing cap-independent translation at levels at least 30-fold higher than picornaviral IRESs in various cell lines.
Effect estimate: at least 30-fold higher
The NRF 5'UTR contains a highly potent internal ribosome entry site (IRES) that directs cap-independent translation much more efficiently than picornaviral IRESs.
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May enable superior gene therapy vectors; leaves open validation in cardiovascular models.
Oumard et al. (2000) studied this question. NRF 5'UTR vs. Picornaviral IRESs (poliovirus, EMCV) was evaluated on Relative IRES activity (firefly/Renilla luciferase ratio) (at least 30-fold higher). The NRF 5'UTR acts as a highly efficient internal ribosome entry site, directing cap-independent translation at levels at least 30-fold higher than picornaviral IRESs in various cell lines.
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